Neurodegeneration Challenge Network (NDCN) Projects
CZI’s Neurodegeneration Challenge Network brings together experimental scientists from diverse research fields, along with computational biologists and physicians, to accelerate fundamental neuroscience and neurodegenerative disease research that leads to an in-depth understanding of healthy brain function and the development of new strategies for treatment and prevention of neurodegenerative disorders.
Showing 69 results
Ankur Jain - Whitehead Institute for Biomedical Research
Jing-Ke Weng - Whitehead Institute for Biomedical Research
Henner Koch - RWTH Aachen University
Deborah Kronenberg-Versteeg - Hertie Institute for Clinical Brain Research, University of Tuebingen
Thomas Wuttke - Hertie Institute for Clinical Brain Research, University of Tuebingen
Sergiu Pasca, MD, PhD - Stanford University
Isaac Chiu, PhD - Harvard Medical School
to leverage an evolutionary perspective to discover how the diversity of molecular states in astrocytes may underlie the resilience of the brain to neurodegeneration.
Maria Antonietta Tosches, PhD - Columbia University
to decipher the role of long-term, systemic brain-body crosstalk on neurodegeneration at the organismal level, using whole-body imaging and click chemistry labeling.
Li Ye, PhD - The Scripps Research Institute
Kristen Brennand - Icahn School of Medicine at Mount Sinai
Jennifer Phillips-Cremins - University of Pennsylvania
Esteban Mazzoni - New York University
Schahram Akbarian - Icahn School of Medicine at Mount Sinai
to unravel the circuit mechanisms underlying early psychiatric symptoms in proteinopathies by combining longitudinal functional recordings with novel post-hoc anatomical and molecular reconstructions.
Sabine Krabbe, PhD - German Center for Neurodegenerative Diseases
Debora Marks, PhD - Harvard University
Philip L. De Jager, MD, PhD - Columbia University (Lead and Clinical PI)
Elizabeth Bradshaw, PhD - Columbia University
Vilas Menon, PhD - Columbia University
Vladislav Petyuk, PhD - Pacific Northwest National Laboratory
Mitchell Guttman, PhD - California Institute of Technology
Michael Keiser, PhD - University of California, San Francisco
to utilize an imaging-based approach to monitor in vivo subcellular autophagy dynamics in the mouse brain, allowing early detection of cell-specific autophagy failure during neurodegeneration.
Tal Laviv, PhD - Tel Aviv University
to investigate metabolic disruptions that impair learning and memory in ALS using super-resolution imaging of mitochondrial stabilization and state-of-the-art mitochondrial ATP imaging.
Vidhya Rangaraju, PhD - Max Planck Florida Institute for Neuroscience
Martin Kampmann, PhD - University of California, San Francisco
Rebecca Ahrens-Nicklas - Children's Hospital of Philadelphia
Elizabeth Bhoj - Children's Hospital of Philadelphia
Marylyn Ritchie - University of Pennsylvania
to identify how the epigenetic regulation of repetitive genetic elements influences human neural transcriptional networks in repeat-associated neurological disorders.
Christopher Douse, PhD - Lund University
Eric Wang, PhD - University of Florida
to use cutting-edge mechanobiology approaches to decipher how cell intrinsic and extrinsic mechanical cues regulate microglia activation during neurophysiology and neurodegeneration.
Alba Diz Muñoz, PhD - European Molecular Biology Laboratory
Ning (Jenny) Jiang, PhD - University of Pennsylvania
Graeme Davis - University of California, San Francisco
Kira Poskanzer - University of California, San Francisco
Jeanne Paz - Gladstone Institute of Neurological Disease and University of California, San Francisco
William Seeley, MD, PhD - University of California, San Francisco (Lead and Clinical PI)
Steven Altschuler, PhD - University of California, San Francisco
Aimee Kao, MD, PhD - University of California, San Francisco
Lani Wu, PhD - University of California, San Francisco
Nicola Allen, PhD - Salk Institute for Biological Studies
Sarah Cohen - University of North Carolina at Chapel Hill
Mohanish Deshmukh - University of North Carolina at Chapel Hill
Serena Yeung - Stanford University
Alejandro Chavez - Columbia University
Serge Przedborski - Columbia University
Vilas Menon - Columbia University
Vincenzo A. Gennarino - Columbia University Irving Medical Center
Xin Jin - Scripps Research Institute
Yang Hu - Stanford University
Stanley Qi - Stanford University
Xin Duan - University of California, San Francisco
Sergej Djuranovic - Washington University School of Medicine in St. Louis
Timothy Miller - Washington University School of Medicine in St. Louis
Slavica Pavlovic Djuranovic - Washington University School of Medicine in St. Loui
to elucidate the role of myelin-forming glia and myelination in neurodegenerative sleep dysregulation using genetic mouse modeling, viral tracing, and Alzheimer’s patient-derived iPSCs.
Erin Gibson, PhD - Stanford University
Inma Cobos, MD, PhD - Stanford University
Gene Yeo, PhD - University of California, San Diego (Lead PI)
Jeffrey D. Rothstein, MD, PhD - Johns Hopkins University (Clinical PI)
Pietro De Camilli - Yale University and HHMI
Hongying Shen - Yale University
Robert Spitale - University of California, Irvine
Leslie Thompson - University of California, Irvine
Elaine Hsiao, PhD - University of California, Los Angeles
Ethan Lippmann, PhD - Vanderbilt University
Ozgun Gokce - Institute for Stroke and Dementia Research
Mikael Simons - Technical University Munich and German Center for Neurodegenerative Diseases
Jeremy Carlton - King's College London
Adrian Isaacs - University College London
Soyon Hong - University College London
Michael Ward - National Institute of Health
Caleb Webber - Cardiff University
to take a multi-pronged approach using optical physiology to elucidate how dysregulation of metabolic crosstalk between neurons & astrocytes contributes to neurodegeneration.
Ghazaleh Ashrafi, PhD - Washington University in St. Louis
Marc Hammarlund - Yale University
Gulcin Pekkurnaz - University of California San Diego
Celeste Karch, PhD - Washington University in St. Louis (Lead PI)
Gregory Day, MD - Mayo Clinic, Florida (Clinical PI)
Carlos Cruchaga, PhD - Washington University in St. Louis
Oscar Harari, PhD - Washington University in St. Louis
Tim Bartels - University College London and UK Dementia Research Institute
Soyon Hong - University College London and UK Dementia Research Institute
Dario Alessi - University of Dundee
Kenneth Harris - University College London
Neil Ranson - Astbury Centre for Structural Molecular Biology, University of Leeds
Martin Giera - Leiden University Medical Center
Rik van der Kant - Vrije Universiteit Amsterdam and Amsterdam University Medical Center
Priyanka Narayan - National Institutes of Health
David Walt, PhD - Harvard University (Lead PI)
Alice-Chen Plotkin, MD - University of Pennsylvania (Clinical PI)
George Church, MD - Harvard University
Wade Harper - Harvard Medical School
Sichen (Susan) Shao - Harvard Medical School
Esteban O. Mazzoni - New York University
Christine Vogel - New York University
Melissa E. Murray - Mayo Clinic Florida
Wilfried Rossoll - Mayo Clinic Florida
Viviana Gradinaru, PhD - California Institute of Technology
Patrik Verstreken, PhD - VIB-KU Leuven (Lead PI)
Wim Vandenberghe, MD, PhD - KU Leuven (Clinical PI)
Dries Braeken, PhD - imec Leuven
Birgitt Schuele, MD - Stanford University
Ernest Arenas, MD, PhD - Karolinska Institutet (Lead PI)
Per Svenningsson, MD, PhD - Karolinska Institutet (Clinical PI)
Sten Linnarsson, PhD - Karolinska Institutet
Mats Nilsson, PhD - Stockholm University
David Simon - Weill Cornell Medicine
Trent Watkins - Baylor College of Medicine
Molly Gale Hammell, PhD - Cold Spring Harbor Laboratory
Cagla Eroglu, PhD - Duke University (Lead PI)
Nicole Calakos, MD, PhD - Duke University (Clinical PI)
Albert La Spada, MD, PhD - Duke University
Mina Gouti - Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Nikolaus Rajewsky - Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Takanari Inoue - Johns Hopkins University
Shigeki Watanabe - Johns Hopkins University
Paul C. Blainey - The Broad Institute of MIT and Harvard
Clotilde Lagier-Tourenne - Massachusetts General Hospital
Ankur Jain - Whitehead Institute for Biomedical Research
Florian T. Merkle, PhD - University of Cambridge
to use in vivo brain imaging of natural sleep to elucidate how the gliovascular unit regulates brain waste clearance to identify targets for the prevention of neurodegeneration.
Rune Enger, MD, PhD - University of Oslo
Alessandro Ori - Leibniz Institute on Aging - Fritz Lipmann Institute
Michael Ward - National Institutes of Health
Hemali Phatnani - New York Genome Center
Lars Steinmetz - European Molecular Biology Laboratory Stanford University
Ivan Marazzi, PhD - Icahn School of Medicine at Mt. Sinai, New York
Antoni Barrientos - University of Miami Health System
Silvia Rouskin - Whitehead Institute for Biomedical Research
Liam Holt - New York University School of Medicine
Hemali Phatnani - New York Genome Center
Ming Guo, MD, PhD - University of California, Los Angeles
Elizabeth J. Videlock, MD, PhD - University of California, Los Angeles
Marc Diamond, MD - UT Southwestern Medical Center (Lead PI)
Charles White, MD - UT Southwestern Medical Center (Clinical PI)
Lukasz Joachimiak, PhD - UT Southwestern Medical Center
Maria Soledad Esposito - Centro Atomico Bariloche - Consejo Nacional de Investigaciones Cientificas y Tecnicas
Ignacio E. Schor - Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas
Wah Chiu - Stanford University
Serena Yeung - Stanford University
Stephanie Moon - University of Michigan
Nils Walter - University of Michigan
Jason Shepherd, PhD - The University of Utah
to generate novel genetic toolkits to determine the roles of oligodendrocytes and to spatiotemporally map myelination in a neural circuit-specific manner during neurodegeneration.
Lu Sun, PhD - University of Texas Southwestern Medical Center
to develop an ultrasound microvascular imaging technique that provides structural (vessel morphology) and functional (neural activities) evaluation of brains affected by neurodegenerative diseases.
Pengfei Song, PhD - University of Illinois
to identify cell engineering strategies that sustain the protective function of microglia as a new therapeutic direction for neurodegenerative diseases.
Frederick Bennett, MD - University of Pennsylvania
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