Single-Cell Epigenomics and Transcriptomics of the Childhood Brain

This project will create a comprehensive cell atlas of the childhood brain by performing joint chromatin and transcriptome profiling at single-cell resolution of healthy tissues from five brain regions and seven donors.

This resource, which will be open to the entire research community through the Human Cell Atlas, will address a lack of a reference for the childhood brain and a lack of representation of the admixed Brazilian genetic background in current references. It will be invaluable for the study of the early stages of brain development and brain-related diseases affecting children.