Our Science Research

The Chan Zuckerberg Initiative produces scientific research to advance our mission to support the science and technology that will make it possible to cure, prevent or manage all diseases by the end of the century. Explore a selection of publications and preprints from across our institutes and grant partners.

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September 18, 2024

How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities

Charlotte Bunne, Yusuf Roohani, Yanay Rosen et al. (2024) | Arxiv

August 28, 2024

Isotype-aware inference of B cell clonal lineage trees from single-cell sequencing data

Leah L. Weber, Derek Reiman, Mrinmoy S. Roddur et al. (2024) | Cell Genomics

July 17, 2024

Symbolic recording of signalling and cis-regulatory element activity to DNA

Chen, W., Choi, J., Li, X. et al. (2024) | Nature

July 16, 2024

Multidimensional Analysis of the Adult Human Heart in Health and Disease Using Hierarchical Phase-Contrast Tomography

Joseph Brunet, Andrew Cook, Claire Walsh et al. (2024) | Radiology

July 16, 2024

Insights and Impact From Five Cycles of Essential Open Source Software for Science

Kate Hertweck, Carly Strasser, Dario Taraborelli

July 10, 2024

Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus

Law, C., Wacleche, V.S., Cao, Y. et al. (2024) | Nature

July 3, 2024

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

Femke M. Feringa, Sascha J. Koppes-den Hertog, Lian Wang et al. (2024) | bioRxiv

July 1, 2024

Single-cell analysis of human diversity in circulating immune cells

Kian Hong Kock, Le Min Tan, Kyung Yeon Han et al. (2024) | bioRxiv

June 27, 2024

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis

Kedia, S., Ji, H., Feng, R. et al. (2024) | Nature Neuroscience

June 26, 2024

protoSpaceJAM: an open-source, customizable and web-accessible design platform for CRISPR/Cas insertional knock-in

Duo Peng, Madhuri Vangipuram, Joan Wong, Manuel D Leonetti (2024) | Nucleic Acids Research

June 22, 2024

Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells

Ivan E. Ivanov, Eduardo Hirata-Miyasaki, Talon Chandler et al. (2023) | bioRxiv

June 11, 2024

Data-driven regularization lowers the size barrier of cryo-EM structure determination

Kimanius, D., Jamali, K., Wilkinson, M.E. et al. (2024) | Nature Methods

June 10, 2024

Omega - harnessing the power of large language models for bioimage analysis

Royer, L.A. (2024) | Nature Methods

June 6, 2024

Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury

Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury | Cell

June 5, 2024

Genome Sequencing for Diagnosing Rare Diseases

Monica Wojcik, Gabrielle Lemire, Eva Berger et al. (2024) | New England Journal of Medicine

June 2, 2024

Surforama: interactive exploration of volumetric data by leveraging 3D surfaces

Kevin A. Yamauchi, Lorenz Lamm, Lorenzo Gaifas et al. (2024) | bioRxiv

May 30, 2024

Active biointegrated living electronics for managing inflammation

Jiuyun Shi, Saehyun Kim, Pengju Li et al. (2024) | Science

May 20, 2024

DeepLabCut: the motion-tracking tool that went viral

Jyoti Madhusoodanan | Nature

May 14, 2024

The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development

Nakagawa S, Carnevali D, Tan X et al. (2024) | Stem Cell Reports

May 10, 2024

Patient-focused drug development in primary sclerosing cholangitis: Insights on patient priorities and involvement in clinical trials

Michael Li, Ruth-Anne Pai, Rachel Gomel et al. (2024) | Hepatology Communications

May 6, 2024

Transthoracic ultrasound localization microscopy of myocardial vasculature in patients

Yan, J., Huang, B., Tonko, J. et al. (2024) | Nature Biomedical Engineering

May 1, 2024

Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities

Graham Wright, Kerry Thompson, Yara Reis et al. (2024) | Journal of Microscopy

April 25, 2024

AI-MARRVEL — A Knowledge-Driven AI System for Diagnosing Mendelian Disorders

Dongxue Mao, Chaozhong Liu, Linhua Wang et al. (2024) | New England Journal of Medicine

April 24, 2024

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Chen, X., Birey, F., Li, MY. et al. (2024) | Nature

April 18, 2024

Molecular determinants and signaling effects of PKA RIα phase separation

Hardy JC, Pool EH, Bruystens JGH et al. (2024) | Molecular Cell

April 17, 2024

Nicheformer: a foundation model for single-cell and spatial omics

Anna C. Shaar, Alejandro Tejada-Lapuerta, Giovanni Palla et al. (2024) | bioRxiv

April 8, 2024

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Wasko, U.N., Jiang, J., Dalton, T.C. et al. (2024) | Nature

January 26, 2024

Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD

Sahba Seddighi, Yue A. Qi, Anna-Leigh Brown et al. (2024) | Science Translational Medicine

January 4, 2024

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

Steven Wells, Daniel Rainbow, Michael Mark et al. (2024) | bioRxiv

October 23, 2023

Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

Adam Glaser, Jayaram Chandrashekar, Joshua Vasquez et al. (2024) | eLife

June 28, 2023

A spatially resolved single-cell genomic atlas of the adult human breast

Kumar, T., Nee, K., Wei, R. et al. (2023) | Nature

March 16, 2023

Public engagement with biomedical science: An analysis of Black, Hispanic, and General Population adults in the United States

Adina Abeles, Kishore Hari, Cory Manento et al. (2023) | bioRxiv

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