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3D Genome Misfolding due to Repeat Instability in Neurodegenerative Disease


Award Collaborative Pairs Pilot Project Awards (2020)
Disease Huntington’s Disease

Project Description

More than 30 inherited disorders are caused by unstable expansion of repetitive DNA sequences termed short tandem repeats, including Huntington’s disease, amyotrophic lateral sclerosis, fragile x syndrome, and Friedreich’s ataxia. This project will investigate the emerging link between the genetic sequence’s higher-order folding patterns and pathologic repeat instability in trinucleotide repeat expansion disorders.


Investigators

Kristen Brennand
Kristen Brennand
Jennifer Phillips-Cremins
Jennifer Phillips-Cremins