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Chromatin Encoding of Repeat Expansion in Neurodegeneration

Award Collaborative Pairs Pilot Project Awards (Cycle 1) (Phase 1), Collaborative Pairs Pilot Project Awards (Cycle 1) (Phase 2)
Focus Area Neurodegeneration

Project Description

More than 30 inherited disorders are caused by unstable expansion of repetitive DNA sequences termed short tandem repeats, including Huntington’s disease, amyotrophic lateral sclerosis, fragile x syndrome, and Friedreich’s ataxia. This project will investigate the emerging link between the genetic sequence’s higher-order folding patterns and pathologic repeat instability in trinucleotide repeat expansion disorders.

 This project was selected for the second phase of the Collaborative Pairs RFA.

Investigators

Kristen Brennand
Kristen Brennand

Icahn School of Medicine at Mount Sinai

Jennifer Phillips-Cremins
Jennifer Phillips-Cremins

University of Pennsylvania

Esteban Mazzoni
Esteban Mazzoni

New York University

Schahram Akbarian
Schahram Akbarian

Icahn School of Medicine at Mount Sinai

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