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A Plant Small-Molecule Discovery Platform to Study Neurodegeneration


Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration

Project Description

RNA and protein aggregation have been implicated in a variety of neurodegenerative disorders, including ALS and Huntington’s Disease. Similar aggregation has not been observed in plant cells, and studies in plants have found that they contain natural compounds that antagonize pathogenic protein aggregation, making them a potential valuable source for small molecule inhibitors of aggregation. This team will develop a new peptide screening platform using plant cells that are engineered to express human neurodegenerative disease-causing proteins and RNAs, in the hopes of uncovering a new way for screening small-molecule-protein interactions in vivo.


Investigators

Ankur Jain
Ankur Jain
Jing-Ke Weng
Jing-Ke Weng