Genetic Modifiers of Microglia-Dependent Disease Etiology

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)

Focus Area Neurodegeneration

Project Description

to integrate multiple CRISPR-screens on imaging platforms to identify oligogenic combinations that modify microglial behavior and exacerbate pathological functions in neurodegenerative pathologies.

Investigators

Cody Smith, PhD

University of Notre Dame

Beth Stevens, PhD

Broad Institute of MIT and Harvard