Mapping Expression Dynamics of Neurodegenerative Disease Genes

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)

Focus Area Neurodegeneration

Project Description

to leverage a CRISPR activation/interference screening in non-coding GWAS regions to elucidate gene regulations underlying the resilience failure in mid-brain DP neurons derived from hPSCs.

Investigators

Atsushi Fukuda, PhD

Tokai University, School of Medicine

Natsuhiko Kumasaka, PhD

Institute of Medical Science, The University of Tokyo