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Neurolipid Atlas


Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration

Project Description

Emerging genetic, epidemiological, and cell biological data has implicated lipid and cholesterol metabolism in a variety of neurodegenerative diseases. However, lipid biology remains an understudied area of research, and there are technical complexities with the application of lipidomic methods to human tissues. This project aims to analyze the lipidome of human iPSC-derived neurons and glia, gene-edited for specific disease variants, and will generate the first map of disease-specific, genotype-specific and cell type-specific changes in the human lipidome associated with neurodegenerative diseases.


Investigators

Martin Giera
Martin Giera
Rik van der Kant
Rik van der Kant