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Project

A Spatial and Lineage Atlas of Bone Marrow Hematopoiesis


Focus Lymphoreticular
Method Epigenetic Sequencing, Multiomics, Single Cell Transcriptomics, Spatial Genomics

Project Summary

This project aims to build the hematopoietic human cell atlas (focusing on blood production) with single cell transcriptomics, multiplexed spatial imaging data, and a pilot lineage-tracing map in vitro. The resulting datasets will be presented via a portal for exploration and data analysis in the context of the wider Human Cell Atlas.

To construct a more representative atlas, this group will include bone marrow samples from donors of African descent. Understanding the bone marrow is important because most of our blood cells derive from stem cells that reside in the marrow, and its regulation is important for maintaining balance and composition in the immune system. Blood count ranges are routinely used to diagnose disease and have historically been developed by sampling mostly individuals of European descent. As individuals of African descent exhibit significantly different blood counts, building more representative blood count ranges could help improve outcomes for diseases, such as early-stage breast cancer in African American women.

This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.


Investigators

Co-Principal Investigators
Sahand Hormoz, PhD
Sahand Hormoz, PhD
Allon Klein, PhD
Allon Klein, PhD

Debora Marks, PhD
Debora Marks, PhD
Ann Mullally, MD
Ann Mullally, MD

Chris Sander, PhD
Chris Sander, PhD
Peng Yin, PhD
Peng Yin, PhD