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Project

A Spatial Cell Type Reference Atlas of the Adult Human Heart


Focus Cardiovascular
Method Epigenetic Sequencing, Single Cell Transcriptomics, Spatial Genomics

Project Summary

The goal of this project is to build a spatially resolved single-cell reference map of the adult human heart.

In addition, this group will work to understand differences in cell type composition or distribution that may underlie cardiovascular disease. Race and ethnicity contribute to differences in the incidence, treatment, and outcomes of cardiovascular disease. In addition to recognized socioeconomic factors, genetic determinants are known to contribute to cardiovascular disease risk factors and cardiovascular pathologies — but how do these risk factors manifest in the identity or composition of various cell types in the heart? The project will incorporate samples from Black and Latinx donors and include collaborators in Canada and Brazil for obtaining these heart tissues.

This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.


Investigators

Co-Principal Investigators
Alexandre Pereira, MD, PhD
Alexandre Pereira, MD, PhD
Christine Seidman, MD
Christine Seidman, MD

Gavin Oudit
Gavin Oudit
Jonathan Seidman, PhD
Jonathan Seidman, PhD

Lars Steinmetz, PhD
Lars Steinmetz, PhD
Matthias Heinig, PhD
Matthias Heinig, PhD

Michela Noseda, MD, PhD
Michela Noseda, MD, PhD
Nikolaus Rajewsky, PhD
Nikolaus Rajewsky, PhD

Norbert Hübner, MD
Norbert Hübner, MD
Sebastian Pott, PhD
Sebastian Pott, PhD

Stuart Cook, MD
Stuart Cook, MD
Collaborators
Anindita Basu, PhD
Anindita Basu, PhD
Dominic Grün, PhD
Dominic Grün, PhD

Fabian Theis, PhD
Fabian Theis, PhD
Sarah Teichmann, PhD
Sarah Teichmann, PhD