A Spatial Cell Type Reference Atlas of the Adult Human Heart
The goal of this project is to build a spatially resolved single-cell reference map of the adult human heart.
In addition, this group will work to understand differences in cell type composition or distribution that may underlie cardiovascular disease. Race and ethnicity contribute to differences in the incidence, treatment, and outcomes of cardiovascular disease. In addition to recognized socioeconomic factors, genetic determinants are known to contribute to cardiovascular disease risk factors and cardiovascular pathologies — but how do these risk factors manifest in the identity or composition of various cell types in the heart? The project will incorporate samples from Black and Latinx donors and include collaborators in Canada and Brazil for obtaining these heart tissues.
This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.