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Project

Cell Atlas of the Neural Retina


Focus Central Nervous System, Eye
Method Single Cell Transcriptomics, Spatial Genomics

Project Summary

This project will establish a cell reference atlas of the human neural retina, build a high-resolution spatial map for all cell types in the retina, and develop single cell classification and integrative analysis software tools.

The prevalence of many common visual disorders differs significantly among ethnic groups, yet the molecular and cellular mechanisms underlying these differences remains elusive. To understand how genetic background contributes to the cell types in the human visual system, this group will perform single-cell RNA-seq and ATAC-seq for retinae donated from female and male African American individuals. This new data will clarify differences in cell subtype composition, gene expression, and pathway activity across ethnic groups and provide important insights to inform the development of targeted therapies.

This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.


Investigators

Co-Principal Investigators
Rui Chen, PhD
Rui Chen, PhD
Margaret DeAngelis, PhD
Margaret DeAngelis, PhD

Kirsten Frieda, PhD
Kirsten Frieda, PhD
Michael Mancini, PhD
Michael Mancini, PhD

Wenyi Wang, PhD
Wenyi Wang, PhD
Collaborators
Ken Chen, PhD
Ken Chen, PhD