Human Immune Variation Across Genetic Backgrounds, Gender and Time

This project seeks to establish the normal range of immune phenotypic variability — both within and across individuals — and assess contributions from genetics and environment, such as diurnal, seasonal, and reproductive cycles and life experience.

To analyze immune cell variations across diverse backgrounds, 315 participants, including over 125 historically underrepresented minorities, enrolled in this research study. The group optimized sample processing protocols for cryopreservation and sample processing and developed software to automate raw sequencing data processing to demultiplexed counts and improve sample genotyping.