Spatiotemporal Multi-Organ Developmental Maps from the Same Individual
Focus Multiple Organs
Method Multiomics, Single Cell Transcriptomics, Spatial Proteomics
This project will build a spatiotemporal atlas of a single individual’s multi-organ developmental program by applying integrated single-cell RNA-seq and 4i spatial maps to primary tissue and matched iPSC-derived organoids from the same individual.
Results & Resources
Using organoid models, this group mapped the human intestinal niche, brain regions, retina, and intestine, and has charted human development through multiple stem cell models. They built an interactive web portal to further explore the endoderm atlas dataset, view interactions, and gain insights from this data. Together, this work has led to several publications and new datasets generated.
Gray Camp, PhD
Smita Krishnaswamy, PhD
Prisca Liberali, PhD
Lucas Pelkmans, PhD
Jason Spence, PhD
Barbara Treutlein, PhD