The Tendon Seed Network will spatially define the transcriptome of extracellular matrix-rich tissues such as tendon across multiple anatomic and micro-anatomic sites. To enable this, the project will develop clinical, laboratory, bioinformatics, and mathematical modelling tools and platforms.
This group will also pilot a patient engagement strategy in order to increase recruitment of ethnically underrepresented donors by developing and growing partnerships with clinical research teams in London and Birmingham. These partnerships will enable better community engagement and collection, analysis, and inclusion of healthy tendon tissue samples from Asian and Black patients in the tendon atlas.
In addition, this team will explore what factors influence participation in musculoskeletal tissue biobanking, with the long-term vision of addressing barriers and developing new partnerships to engage larger numbers of ethnically diverse donors in ongoing and future studies.