Priscilla Chan is the co-founder and co-CEO of the Chan Zuckerberg Initiative, where she leads efforts to advance biomedical research and technology to help scientists cure, prevent, or manage all disease by the end of this century. As a pediatrician, her firsthand experience caring for patients has fueled her commitment to accelerating scientific discovery. Priscilla’s leadership at CZI has focused on harnessing AI, building cutting-edge research tools, and funding innovative science to unlock new insights into human biology. She earned her bachelor's degree in biology from Harvard University and her doctor of medicine from the University of California, San Francisco, where she also completed her pediatrics residency.

Lori Goler is president of the Chan Zuckerberg Initiative, where she oversees CZI’s work in science and education, leads the organization's operations and empowers teams to deliver with purpose and impact. She previously served as chief people officer at Meta, overseeing the company’s global people strategy and operations over a 16-year period during which Meta scaled from approximately 500 people to more than 80,000 people and was consistently celebrated as one of the best places to work. Earlier in her career, she was General Manager of eBay Stores, a founding executive at eStyle, and held business planning roles at The Walt Disney Company. Lori served on the Board of Directors of Stanford Health Care for nearly a decade, gaining firsthand insight into the power of science and technology to improve lives. She holds a bachelor’s degree from Yale University, an MBA from Harvard Business School, and a master’s in public policy from Harvard’s Kennedy School of Government.

Mark Kim is the general counsel for the Chan Zuckerberg Initiative. Before joining CZI, Mark was a partner at Munger, Tolles & Olson (MTO), where he practiced corporate law, with a focus on mergers and acquisitions, joint ventures and corporate governance. While at MTO, Mark played an integral role in the structuring and establishment of both CZI and Biohub and represented CZI and Biohub as lead outside counsel. Mark received his law degree from Yale Law School, where he served as a student director for the Advocacy for Parents and Children legal clinic, and received his undergraduate degree from Harvard College. Following law school, Mark clerked for Judge Pamela Ann Rymer on the United States Court of Appeals for the Ninth Circuit.

Alex Rives is head of science at the Chan Zuckerberg Initiative, leading its work at the intersection of artificial intelligence and biology. Alex was a founder and chief scientist at EvolutionaryScale, a public-benefit company developing AI to accelerate scientific discovery in biology, and delivering transformative AI systems and applications to benefit the global scientific community. Rives is a core institute member at the Broad Institute, and an assistant professor in the Department of Electrical Engineering and Computer Science at MIT. He will continue to be affiliated with Broad Institute and MIT.

As a scientist, Rives has done pioneering work in artificial intelligence for biology. He started and led the Evolutionary Scale Modeling, or ESM, project at Meta’s fundamental AI research lab, which developed the first large scale transformer language models for proteins. The ESM models are widely recognized as a breakthrough in artificial intelligence for biology, and opened the field of language modeling in biology. These models are used by scientists worldwide, enabling applications including designing therapeutic proteins such as antibodies, predicting the effects of mutations in the human genome, illuminating evolutionary history, discovering new proteins, and creating models of the cell. Rives earned a bachelor’s degree in philosophy and biology from Yale University and a doctorate in computer science from New York University.

Andrea Califano is president of systems biology and head of Biohub New York. Before joining Biohub, he was the Clyde and Helen Wu Professor of Chemical and Systems Biology at Columbia University Vagelos College of Physicians and Surgeons, holding cross-appointments in Biochemistry and Molecular Biophysics, Biomedical Informatics, and Medicine. From 2013 to 2023, he served as founding chair of Columbia’s Department of Systems Biology and director of the JP Sulzberger Columbia Genome Center. A native of Italy, Califano earned his doctorate in physics from the University of Florence and completed postdoctoral work at MIT. He began his career at IBM’s TJ Watson Research Center, where he became program director of the Computational Biology Center, co-founded First Genetic Trust Inc. in 2000, and joined Columbia in 2003.

An internationally recognized pioneer in reverse-engineering gene regulatory networks, Califano discovered Master Regulator proteins that drive the transcriptional states of cancer cells across tumor types. His work has led to insights into tumorigenesis and drug response, spurring multiple clinical trials in cancers such as breast, pancreatic, and glioblastoma. He serves on numerous national scientific and editorial boards, including at the MIT Koch Cancer Center and Dana-Farber Cancer Institute. Califano is a member of the National Academy of Medicine and a fellow of AAAS, the IEEE, and the American Association for Cancer Research Academy. His honors include two NCI Outstanding Investigator Awards and the 2023 NCI Alfred G. Knudson Award in Cancer Genetics.

Shana Kelley serves as president, bioengineering and head of Biohub, Chicago. Prior to joining Biohub, Shana has been the Neena B. Schwartz Professor at Northwestern in the Departments of Chemistry, Biomedical Engineering, and Biochemistry & Molecular Genetics. The Kelley research group works in a variety of areas spanning bio analytical technology development and has pioneered new methods for tracking molecular and cellular analytes with unprecedented sensitivity. Kelley’s work has been recognized with the ACS Inorganic Nanoscience Award, the ACS Arthur Doolittle Award, the Pittsburgh Conference Achievement Award, the Steacie Prize, an Alfred P. Sloan Research Fellowship, a Camille Dreyfus Teacher-Scholar award, a NSF CAREER Award, and a Dreyfus New Faculty Award. She was also named a “Top 100 Innovator” by MIT’s Technology Review.

Kelley is a member of the American Academy of Arts and Sciences, a Guggenheim Fellow, a Fellow of the Royal Society of Canada, the Canadian Academy of Health Sciences, and the American Institute of Biological and Medical Engineering. Kelley is an inventor on over 50 patents issued worldwide and a successful entrepreneur. She is a founder of four molecular diagnostics companies, GeneOhm Sciences (acquired by Becton Dickinson in 2005), Xagenic Inc. (acquired by General Atomics in 2017), CTRL Therapeutics (founded in 2019), and Arma Biosciences (founded in 2021). She is an Associate Editor for ACS Sensors, and an Editorial Advisory Board Member for the Journal of the American Chemical Society, Nano Letters, and ACS Nano. Kelley was a member of the Executive Leadership team for Medicine by Design, a $114 million multidisciplinary, multi-institutional initiative focused on engineering approaches to regenerative medicine, and was a theme leader for the Nanomedicine Innovation Network, a government-funded effort to unite nanotechnology-focused researchers across Canada. She was also the founder and Director of PRiME, which was launched at the University of Toronto to unite the life sciences, engineering, and clinical communities.

Tom Sercu serves as vice president of AI and engineering. Previously, he was co-founder and vice president of engineering at EvolutionaryScale, playing a key role in building the company. His contributions at EvolutionaryScale span across engineering, AI research, leading the company’s organization building and hiring, and setting up much of the operations.

Before becoming an entrepreneur, Tom was an AI research engineer and research manager. His research expertise spans several areas of deep learning, including bridging domains by applying breakthrough neural architectures from computer vision to speech recognition at New York University and IBM Research's T.J. Watson Research Center. He later worked on the theoretical foundations of generative models, precursors to today’s generative AI era, before focusing on the intersection of foundational AI and biology. As co-leader of the protein team at Meta AI (FAIR) in New York, Tom developed with the ESM the first transformer protein language model, ESM-1, followed by ESM-1b, ESM2, ESMFold, and the ESM Atlas resource.

Sandra Liu Huang is the president of Learning Commons. A product and philanthropic leader, Sandra brings together a world-class engineering team, researchers, educators, and developers at Learning Commons to build AI infrastructure that better connects the ways students learn with the tools they learn with.

Previously, Sandra served as the head of product at Quora, a platform for gaining and sharing knowledge, where she served as their first product manager and oversaw its growth to 100 million monthly unique users. Sandra also led product development in roles at Google and Facebook, where she managed complex, interdisciplinary teams building tools and products such as Google AdWords and Google AdSense. She holds bachelor's and master's degrees from Stanford University.

Dan Quine is senior director of engineering at Learning Commons. Dan is a computer scientist and technology leader who has worked at major firms, including Apple and Google. His early work focused on machine-learning methods for pattern recognition and human-computer collaboration.

During his career, he has held roles such as CTO of the live-music startup Songkick and VP of engineering at analytics firm Mode Analytics. He received a B.Sc. in Computer Science from the University of Leeds and earned his Ph.D. in Artificial Intelligence from Leeds in 1995.

Raymonde M. Charles is the vice president of communications for Learning Commons and ventures. For more than two decades, Raymonde has served as an advisor to senior leaders in philanthropy, government, and the nonprofit sector. Her leadership experience includes serving as Deputy Press Secretary to the U.S. Secretary of Education and leading communications for the Children’s Defense Fund, national and local political campaigns, and in the U.S. House of Representatives. Raymonde has a bachelor’s degree from Rhode Island College.