Career Opportunities

You will lead our strategic planning process in Technology and create and maintain strategic alignment between priorities and the needs with stakeholders across Science, including our scientific leaders across the Biohub network. You'll be a strategic thought partner for the Head of Technology in Science.

The Team At CZI, we pair technology with grantmaking to equip educators, families and students with tools that integrate high-quality research, practices and content to unlock the full potential of every student, no matter who they are or where they live. From program conception to software feature design, we center our work on student and educator voices to help educators address the day-to-day challenges in their classrooms. Since 2015, our grant investments have helped catalyze new tools, practices, and measures designed to foster whole-child outcomes. We leverage technology to provide research-based practices in products that help teachers connect with students and tailor learning experiences to individual student needs. At our core, we are builders and our unique builder philanthropy approach is what sets us apart from other education funders. Take a closer look at the highlights and significant milestones of CZI’s first eight years of education work. The Opportunity Educators are already using AI-based tools in various ways—including generating lesson plans, creating classroom materials such as tests and assignments, and helping differentiate instruction for students. At CZI, we are inspired and excited about the possibilities and promise of AI to accelerate the availability of research-backed practices at scale. We are actively and thoughtfully exploring how to incorporate AI into products in close partnership with researchers, experts, and educators. As a Senior Machine Learning Engineer on the AI/ML team, you will play a crucial role in translating cutting-edge AI research and exploration into tangible tools and capabilities. You'll work on applying and scaling machine learning models to address specific educational challenges. You’ll have the opportunity to own significant features and contribute to the design of robust, scalable ML systems.

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems — paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI’s work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. The Opportunity We are seeking a Senior Product Manager with deep expertise at the intersection of artificial intelligence and biology. In this role, you will lead the development of innovative products that apply state-of-the-art AI to accelerate biological research. As part of the Science Technology (SciTech) team, you will shape products that empower both computational and experimental researchers to use AI for in silico experimentation, hypothesis generation, data interpretation, and biological modeling. You will work across disciplines to identify high-impact opportunities where AI can meaningfully accelerate scientific progress, and translate them into impactful, scalable tools integrated within the CZI Virtual Cells Platform. Examples include: Multi-modal workflows for users to run inference on models using their own data for key tasks like data annotation and comparing data to a reference (e.g. healthy vs disease). Tools that enable researchers to run and visualize in silico experiments using AI models, e.g. simulate how specific gene knockouts affect cell behavior in a virtual T-cell model. AI agents that assist experimental biologists in designing experiments by integrating prior datasets, model predictions, and literature insights.

You will play a pivotal role in managing the Airtable database to track data progress from generation by lab partners through processing, sequencing, ingestion, and registration. This role will collaborate closely with an accountable partner(s) within the function, who will oversee the end-to-end strategy, rollout of functional activities, and resolution of challenges. As the central processing hub, the Project Coordinator will ensure seamless coordination between lab partners, processing partners, and functional leads, maintaining transparency and accountability throughout the data lifecycle.

You will be responsible for shaping and supporting an internal communications program that informs, engages, and inspires employees by bringing CZI’s mission and work to life, fostering a clear understanding of CZI’s strategies across our science and education efforts, and advising the leadership team on messaging and delivery.

You will lead the creation of groundbreaking datasets that power our scientific grand challenge to instrument tissues to understand inflammation — a cutting-edge initiative aimed at determining the role of inflammation in disease and the molecular mechanisms through which it acts.

You will shape the Data Science function for Insights, Analytics & Open Research Team, driving data strategy and implementation to monitor progress, assess scientific impact, and track the competitive landscape of CZI’s work in science.

You will ensure that CZI remains a global leader in leveraging data to advance biomedical science and change medicine for generations to come. The leader will serve as the connective tissue between experimental data generation and computational modeling efforts, ensuring the initiative builds a data foundation that enables breakthrough biological insights. The Vice President of Data will be a collaborative, forward-looking leader who thrives in a dynamic, fast-paced environment focused on delivering transformative science.

The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Central Operations & Partners team provides the support needed to push this work forward. Central Operations & Partners consists of our Brand & Communications, Community, Facilities, Finance, Infrastructure/IT Operations/Business Systems, Initiative Operations, People, Real Estate/Workplace/Facilities/Security, Research & Learning, and Ventures teams. These teams provide the essential operations, services, and strategies needed to support CZI’s progress toward achieving its mission to build a better future for everyone. Our Central Tech team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. The Opportunity We are seeking a visionary and experienced Senior Manager to lead our End User Support team. This is a high-impact leadership role that requires both strategic foresight and hands-on execution. You will be responsible for shaping the future of end-user service delivery at CZI—defining what exceptional support looks like and building the systems, team, and culture to achieve it. You’ll lead a high-performing team that supports a diverse and distributed workforce, ensuring seamless and secure access to the tools and services employees need to thrive. Your leadership will help transform support into a proactive, data-driven, and automation-enabled function that scales with CZI’s growing needs.

You will lead a team of software engineers, data scientists and machine learning engineers who build and maintain our rapidly growing set of evaluators that measure the educational suitability of AI systems.

The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Central Operations & Partners team provides the support needed to push this work forward. Central Operations & Partners consists of our Brand & Communications, Facilities, Finance, Infrastructure/IT Operations/Business Systems, Initiative Operations, People, Real Estate/Workplace/Facilities/Security, Research & Learning, and Ventures teams. These teams provide the essential operations, services, and strategies needed to support CZI’s progress toward achieving its mission to build a better future for everyone. Our Central Tech team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. The Opportunity As the Physical Security Systems Engineer, you will shape and advance cutting-edge physical security systems across CZI and the Chan Zuckerberg Biohub. You will drive the design, implementation, and optimization of our Access Control Systems, Video Management Systems, and other physical security infrastructure. From managing large-scale installations and system upgrades to developing smart API integrations, your work will directly enhance the safety and operational efficiency of our environment. With access to top-tier tools and collaboration with cross-functional teams, you’ll solve complex challenges, explore emerging technologies, and make impactful data-driven decisions.

You will lead a team to create and maintain an efficient, engaging, and positive onsite experience, implementing industry best practices to anticipate problems and proactively support the team to find solutions.