Integrated Computational and Experimental Approaches to Dissect Cell Type Variation

To dissect cell-type variation in human substantia nigra and locus coeruleus using integrated computational and experimental approaches.

Macosko and Costa generated pilot data from difficult regions of the brain that are critical for neurodegeneration – the substantia and locus coeruleus. They released a protocol detailing frozen nuclei extraction and they have developed a computational tool (LIGER) to integrate diverse data types. This work is described in a preprint available on bioRxiv.