Statistical Analysis and Comprehension of the Human Cell Atlas in R / Bioconductor: Access and Scalable Infrastructure

To provide R / Bioconductor software to provide coherent programmatic interface to the HCA, and to enable scalable interactive statistical analysis of single-cell data.

The Irizarry lab worked on statistical methodology for normalization, feature selection and dimension reduction for single-cell RNA-seq. Their tool, glm-pca, is openly available and a preprint has been released detailing their work.