Mapping Non-AUG Translation Initiation in Neurodegeneration

Award Collaborative Pairs Pilot Project Awards (Cycle 2) (Phase 1)

Focus Area Neurodegeneration

Project Description

to use cryo-electron microscopy and biochemical approaches to elucidate the mechanism underlying repeat-associated non-AUG translation initiation in neurodegeneration associated with short tandem repeat expansion disorders.

Investigators

Jay Brito Querido, PhD

University of Michigan

Peter K. Todd, MD, PhD

University of Michigan