Promoting Neuronal Cell Death to Mitigate Widespread Neurodegeneration
Award
Collaborative Pairs Pilot Project Awards (Cycle 1) (Phase 1)
Focus Area
Neurodegeneration
Project Description
Extensive cell death is a hallmark of neurodegenerative disease. Early cell death is typically limited and regional, and then spreads as the disease progresses. This project proposes a new way to think about neuronal cell death, investigating the idea that early cell death of diseased neurons may initially serve as a protective mechanism that slows disease spread. The team will also test the hypothesis that targeting these early “pathogenic” neurons for more rapid elimination may suppress disease progression.
Investigators
![David Simon](https://chanzuckerberg.com/wp-content/uploads/2020/08/DavidSimon_pic-David-Simon.jpg)
David Simon
![Trent Watkins](https://chanzuckerberg.com/wp-content/uploads/2020/08/Watkins-Trent.193038AEE5E-Trent-Watkins-Trent-Watkins.jpg)
Trent Watkins