Single-Cell Analysis of Inflammation Grantees

A Data-Driven Approach to Understanding Liver and Lung Diseases

Investigators Cole Trapnell, PhD (University of Washington)
Bruce Trapnell, MS, MD (Cincinnati Children's Hospital Medical Center)
Yiing Lin, MD (Washington University in St. Louis)

Focus Fibrosis, Liver, Lung

Analyzing How Inflammation Affects the Aging Brain

Investigators Anne Brunet, PhD (Stanford University)
Ami Bhatt, MD, PhD (Stanford University)
Chris Garcia, PhD (Stanford University)

Focus Aging, Microbiome, Modeling, Neuroimmune, Tools & Technologies

Deciphering Inflammatory Memory in Wound Healing

Investigators Giacomo Donati, PhD (University of Torino)
Ken Natsuga, MD, PhD (Hokkaido University Hospital)
Tzachi Hagai, PhD (Tel Aviv University)

Focus Skin

Decoding Inflammation through Immune Cell Behavior

Investigators Eduardo Reategui, PhD (Ohio State University)
Tim Laemmermann, PhD (Max Planck Institute of Immunobiology and Epigenetics)

Focus Tools & Technologies

Decoding Inter-Organ Inflammatory Signaling at the Single-Cell Level

Investigators Nicolas Chevrier, PhD (The University of Chicago)
Andrew Ferguson, PhD (The University of Chicago)
Savas Tay, PhD (The University of Chicago)

Focus Tools & Technologies

Exploring Single-Cell Sequencing of Liver Inflammation

Investigators Bruce Wang, MD (University of California, San Francisco)
Michele Tana, MD, MHS (University of California, San Francisco)

Focus Liver

High-Resolution Profiling of Body Fat Immune Cells in Brazilian Populations

Investigators Marcelo Alves da Silva Mori, PhD (University of Campinas, Brazil)
Mariana Boroni, MSc, PhD (Brazilian National Cancer Institute)
Pedro Moraes-Vieira, DVM, PhD (University of Campinas, Brazil)

Focus Immunology, Obesity

How the Gut and Nervous System Control the Spread of Infection

Investigators James Gagnon, PhD (University of Utah)
Kristen Kwan, PhD (University of Utah)
Nels Elde, PhD (University of Utah)

Focus Neuroimmune

How Western Lifestyles Modify Immune Responses in East African Populations

Investigators Julien Ayroles, PhD (Princeton University)
Brittany Adamson, PhD (Princeton University)
Michael Mina, MD, PhD (Harvard University)

Focus Genetic Diversity

Identifying Neuroimmune Mechanisms Triggered by the Flu

Investigators Colin Reardon, PhD (University of California, Davis)
Nicole Baumgarth, DVM, PhD (University of California, Davis)

Focus Lung, Neuroimmune

Imaging Gut Immune Cells and Microbes to Understand Health and Disease

Investigators Lucy Erin O'Brien, PhD (Stanford University)
Kerwyn Casey Huang, MPhil, PhD (Stanford University)

Focus Gut, Microbiome, Modeling, Tools & Technologies

Inflammation in Pediatric Pulmonary Diseases

Investigators Melanie Neeland, PhD (Murdoch Children’s Research Institute)
Alicia Oshlack, PhD (Peter MacCallum Cancer Centre)
Sarath Ranganathan, MB ChB, MRCP, FRCPCH, FRACP, PhD (Murdoch Children’s Research Institute)

Focus Lung, Tools & Technologies

Investigating Similarities and Differences Between Chronic and Acute Inflammation

Investigators Marcelo Dietrich, MD, PhD (Yale University)
Andrew Wang, MD, PhD (Yale University)
Noah Palm, PhD (Yale University)

Focus Gut, Metabolism, Microbiome, Neuroimmune

Local Inflammation in Atherosclerosis

Investigators Chiara Giannarelli, MD, PhD (Icahn School of Medicine at Mount Sinai)
Dan Avi Landau, MD, PhD (Weill Cornell Medicine, New York Genome Center)
Minji Byun, PhD (Icahn School of Medicine at Mount Sinai)

Focus Aging, Cardiovascular, Tools & Technologies

Mapping Human Inflammatory Responses in Ethnically Diverse Groups

Investigators Anita Milicic, MSc, DPhil (University of Oxford)
Calliope Dendrou, PhD (University of Oxford)
Mark Coles, PhD (University of Oxford)

Focus Vaccine Adjuvants

Mapping Skin Inflammation in Rare Disease Patients

Investigators John Tsang, PhD (National Institute of Allergy and Infectious Diseases, National Institutes of Health)
Rachel Sparks, MD, MPH (National Institute of Allergy and Infectious Diseases, National Institutes of Health)
Ronald Germain, MD, PhD (National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Focus Modeling, Skin

Probing the Role of Inflammation in Heart Regeneration

Investigators Robin Choudhury, MA, DM, FRCP (University of Oxford)
Mathilda Mommersteeg, PhD (University of Oxford)
Paul Riley, PhD (University of Oxford)

Focus Cardiovascular

Single-Cell Approaches to Decipher Central Nervous System Trauma

Investigators Jony Kipnis, PhD (Washington University School of Medicine in St. Louis)
Kodi Ravichandran, PhD (University of Virginia)

Focus Neuroimmune

Studying Vascular Disease in Diverse Patients

Investigators Joseph Wu, MD, PhD (Stanford University)
Elsie Gyang Ross, MD (Stanford University)
Philip S. Tsao, PhD (Stanford University)

Focus Aging, Cardiovascular, Genetic Diversity

Tools to Manipulate Gene Expression in 3D Models of Human Disease

Investigators Nicole Coufal, MD, PhD (University of California, San Diego)
Christopher Glass, MD, PhD (University of California, San Diego)
Gene Yeo, PhD, MBA (University of California, San Diego)

Focus Neuroimmune

Understanding How Age Influences Susceptibility to Coronavirus Infection

Investigators Vineet Menachery, PhD (University of Texas Medical Branch at Galveston)
Andrew Routh, PhD (University of Texas Medical Branch at Galveston)

Focus Aging, Lung, Tools & Technologies, Viral Infection

Understanding How Maternal Inflammation Impacts Pregnancy

Investigators Kellie Ann Jurado, PhD (University of Pennsylvania)
Dan Dongeun Huh, PhD (University of Pennsylvania)
Monica Mainigi, MD (University of Pennsylvania)

Focus Maternal & Fetal Health

Understanding How Stress and Social Disparity Affect Preterm Birth

Investigators Jingjing Li, PhD (University of California, San Francisco)
David K. Stevenson, MD (Stanford University)
Gary M. Shaw, DrPH (Stanford University)

Focus Maternal & Fetal Health

Understanding Inflammation’s Role in Childhood Obesity

Investigators Jorge Henao-Mejia, MD, PhD (University of Pennsylvania)
Golnaz Vahedi, PhD (University of Pennsylvania)
Sarah Henrickson, MD, PhD (Children’s Hospital of Philadelphia, University of Pennsylvania )

Focus Obesity

Understanding Organism-Wide Inflammation After Heart Injury

Investigators James Lo, MD, PhD (Weill Cornell Medicine)
Doron Betel, PhD (Weill Cornell Medicine)
Jingli Cao, PhD (Weill Cornell Medicine)

Focus Cardiovascular

Understanding Pediatric Inflammatory Bowel Disease

Investigators Hiutung Chu, PhD (University of California, San Diego )
David Gonzalez, PhD (University of California, San Diego )
Mamata Sivagnanam, MD (University of California, San Diego | Rady Children’s Hospital, San Diego)

Focus 3D Models, Gut, Microbiome

Understanding the Impact of Urbanization on Immune Systems in Rural and Urban Africa

Investigators Ahmed Mahfouz, PhD (Leiden University Medical Center)
Maria Yazdanbakhsh, PhD (Leiden University Medical Center)
Moustapha Mbow, PhD (Cheikh Anta Diop University)

Focus Immune, Tools & Technologies

Unraveling Neuroimmune Interactions at the Single-Cell Level

Investigators Isaac Chiu, PhD (Harvard Medical School)
Henrique Veiga-Fernandes, PhD (Champalimaud Center for the Unknown )
Stephen Liberles, PhD (Harvard Medical School, Howard Hughes Medical Institute)

Focus Neuroimmune

Visualizing B- and T-cell Clones Associated in Autoimmunity

Investigators Jeffrey Moffitt, PhD (Boston Children's Hospital)
Michael Carroll, PhD (Boston Children's Hospital)

Focus Autoimmunity, Tools & Technologies