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Project

Benchmarking Developing and Adult Kidney with Organoids at Single Cell Resolution


Focus Urinary
Method Epigenetic Sequencing, Single Cell Transcriptomics

Project Summary

This network will build a single-cell atlas of a healthy developing and adult human kidney, across ages and sex, and benchmark these data against cell types in human kidney organoids, or 3D cell culures that mimic human organs.

This group will also pilot a patient engagement strategy to include samples from African American donors in the kidney atlas and to recruit people from understudied racial and ethnic populations for future translational research. Additionally, they will hire a clinical coordinator whose racial and ethnic background reflects the population served by Boston University Medical Center. This coordinator will partner community members with healthcare centers, policymakers, and researchers, as well as provide guidance on best practices for patient engagement, retention, and the establishment of a patient advisory board.

This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.


Investigators

Co-Principal Investigators
Steven Chang, MD
Steven Chang, MD
Benjamin Humphreys, MD, PhD
Benjamin Humphreys, MD, PhD

Andrew McMahon, PhD
Andrew McMahon, PhD
Stefan Tullius, MD, PhD
Stefan Tullius, MD, PhD

Sushrut Waikar, MD, MPH
Sushrut Waikar, MD, MPH
Bo Zhang, PhD
Bo Zhang, PhD

Collaborators
Nils Lindstrom, PhD
Nils Lindstrom, PhD
Tracy Battaglia, MD, MPH
Tracy Battaglia, MD, MPH