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Project

Inferring Cell Interactions: Spatial Organization of Human Lymph Nodes


Focus Lymphoreticular
Method Multiomics, Single Cell Transcriptomics, Spatial Genomics

Project Summary

This project aims to combine spatially-resolved and single-cell transcriptional profiling to develop a systematic method for inferring cell-cell interactions, and to apply that method to create a high-resolution spatial atlas of healthy human lymph nodes. To help ensure an ethnically representative population of healthy individuals, this group will partner with another CZI Seed Network at Columbia Medical School to leverage an existing relationship with LivOnNY and procure and analyze additional lymph node samples from Black, Latinx, and Asian donors.

This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.


Investigators

Co-Principal Investigators
Donna Farber, PhD
Donna Farber, PhD
Peter Kharchenko, PhD
Peter Kharchenko, PhD

Jeffrey Moffit, PhD
Jeffrey Moffit, PhD
Peter Sims, MD
Peter Sims, MD

Catherine Wu, MD
Catherine Wu, MD