Pediatric Networks for the Human Cell Atlas
These projects support researchers to contribute pediatric tissue samples to the global Human Cell Atlas as a foundation for understanding how cells and organs mature and relate to disease onset in children. Read our Medium post.
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This team will build a single-cell pediatric atlas of healthy peripheral blood myeloid and lymphoid cell development, following Bacillus Calmette-Guérin (BCG) vaccine induced trained immunity in the first year of life.
This team hopes to understand the single-cell biology of the nasopharyngeal and oral mucosa in children living within globally representative communities.
This team will develop a roadmap of pediatric ovarian maturation to better understand gonadal pathophysiology.
This project seeks to generate an atlas of adipose tissue from donors of different ancestries in abdominal, subcutaneous, and cardiac depots, which are known contributors to child and adult health.
This team will build a single-cell atlas of the pediatric intestine to understand how the human intestine matures in childhood and adult intestinal diseases.
This team will build a longitudinal heart atlas from infant, childhood, and adolescent tissues across multiple ancestries.
This team will develop a comprehensive immune and epithelial cell atlas of the healthy pediatric airway as an open-access reference for understanding globally significant childhood lung diseases.
This team will examine the complexity and maturation of human tissue and pluripotent stem cell-derived organoid models, which are essential for modeling human organ homeostasis and pediatric diseases.
This team will map early gut development across populations with diverse ancestry, and examine social determinants of health and environmental exposures.
This project will create an ancestrally diverse, open access, multi-omic atlas of the nose, mouth, and airways from birth through adolescence.
This team will produce an interactive single-cell genome and spatial browser so datasets are accessible across sites and to the wider scientific community.
This team will combine single-cell, single-nucleus, and spatial transcriptomics, integrating the results to establish a robust reference atlas throughout pediatric skeletal muscle development.
This team will generate a comprehensive spatially resolved, single-cell atlas of human pediatric ocular tissue.
This team will analyze liver tissue through stages of normal pediatric development across diverse ancestries and build single-cell maps to share with the scientific community that define cell types, transcriptional heterogeneity, and spatial organization of a healthy liver.
This team will develop a comprehensive cell atlas of the childhood brain by performing joint chromatin and transcriptome profiling at single-cell resolution of healthy tissues.
This team will generate and analyze foundational data from healthy samples necessary to provide insights relevant for pediatric inflammatory and infectious skin conditions, genetic skin diseases, and disorders specific to historically marginalized communities.
This team will develop a comprehensive, time- and space-resolved multi-omic single-cell atlas of the developing hematopoietic and immune system that benefits the entire scientific and clinical community.
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