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Project

A Comprehensive Single Cell Atlas of the Human Kidney


Focus Urinary
Method Epigenetic Sequencing, Single Cell Transcriptomics, Spatial Genomics, Spatial Proteomics

Project Summary

This network will develop a comprehensive, validated atlas of the human kidney at single cell resolution open to the entire scientific and clinical community.


Results & Resources

This group developed methodologies for single-nucleus isolation, sequencing preparation, and slide-sequencing from human kidney samples. They also designed computational methods for slide-sequencing analysis to aid spatial localization of the human kidney transcriptome. With these tools and techniques, they generated data from 69 samples and published several manuscripts, including three that used published and unpublished data to uncover new insights related to the susceptibility of kidney cells to COVID-19.


Investigators

Co-Principal Investigators
Fei Chen, PhD
Fei Chen, PhD
Menna Clatworthy, MBBCh, PhD, FRCP
Menna Clatworthy, MBBCh, PhD, FRCP

Anna Greka, MD, PhD
Anna Greka, MD, PhD
Matthias Kretzler, MD
Matthias Kretzler, MD

Minnie Sarwal, MD
Minnie Sarwal, MD
Olga Troyanskaya, PhD
Olga Troyanskaya, PhD

Collaborators
Aviv Regev, PhD
Aviv Regev, PhD
Sarah Teichmann, PhD
Sarah Teichmann, PhD

Jimmie Ye, PhD
Jimmie Ye, PhD