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Our Science Research
The Chan Zuckerberg Initiative produces scientific research to advance our mission to support the science and technology that will make it possible to cure, prevent or manage all diseases by the end of the century. Explore a selection of publications and preprints from across our institutes and grant partners.
Exploring the ‘Digital Age of Biology’
Unlocking Human Health With AI-powered Virtual Cells
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Symbolic recording of signalling and cis-regulatory element activity to DNA
Chen, W., Choi, J., Li, X. et al. (2024) | Nature
Multidimensional Analysis of the Adult Human Heart in Health and Disease Using Hierarchical Phase-Contrast Tomography
Joseph Brunet, Andrew Cook, Claire Walsh et al. (2024) | Radiology
Insights and Impact From Five Cycles of Essential Open Source Software for Science
Kate Hertweck, Carly Strasser, Dario Taraborelli
Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
Law, C., Wacleche, V.S., Cao, Y. et al. (2024) | Nature
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
Femke M. Feringa, Sascha J. Koppes-den Hertog, Lian Wang et al. (2024) | bioRxiv
Single-cell analysis of human diversity in circulating immune cells
Kian Hong Kock, Le Min Tan, Kyung Yeon Han et al. (2024) | bioRxiv
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis
Kedia, S., Ji, H., Feng, R. et al. (2024) | Nature Neuroscience
protoSpaceJAM: an open-source, customizable and web-accessible design platform for CRISPR/Cas insertional knock-in
Duo Peng, Madhuri Vangipuram, Joan Wong, Manuel D Leonetti (2024) | Nucleic Acids Research
Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells
Ivan E. Ivanov, Eduardo Hirata-Miyasaki, Talon Chandler et al. (2023) | bioRxiv
Data-driven regularization lowers the size barrier of cryo-EM structure determination
Kimanius, D., Jamali, K., Wilkinson, M.E. et al. (2024) | Nature Methods
Omega - harnessing the power of large language models for bioimage analysis
Royer, L.A. (2024) | Nature Methods
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury | Cell
Genome Sequencing for Diagnosing Rare Diseases
Monica Wojcik, Gabrielle Lemire, Eva Berger et al. (2024) | New England Journal of Medicine
Surforama: interactive exploration of volumetric data by leveraging 3D surfaces
Kevin A. Yamauchi, Lorenz Lamm, Lorenzo Gaifas et al. (2024) | bioRxiv
Active biointegrated living electronics for managing inflammation
Jiuyun Shi, Saehyun Kim, Pengju Li et al. (2024) | Science
DeepLabCut: the motion-tracking tool that went viral
Jyoti Madhusoodanan | Nature
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development
Nakagawa S, Carnevali D, Tan X et al. (2024) | Stem Cell Reports
Patient-focused drug development in primary sclerosing cholangitis: Insights on patient priorities and involvement in clinical trials
Michael Li, Ruth-Anne Pai, Rachel Gomel et al. (2024) | Hepatology Communications
Transthoracic ultrasound localization microscopy of myocardial vasculature in patients
Yan, J., Huang, B., Tonko, J. et al. (2024) | Nature Biomedical Engineering
Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities
Graham Wright, Kerry Thompson, Yara Reis et al. (2024) | Journal of Microscopy
AI-MARRVEL — A Knowledge-Driven AI System for Diagnosing Mendelian Disorders
Dongxue Mao, Chaozhong Liu, Linhua Wang et al. (2024) | New England Journal of Medicine
Antisense oligonucleotide therapeutic approach for Timothy syndrome
Chen, X., Birey, F., Li, MY. et al. (2024) | Nature
Molecular determinants and signaling effects of PKA RIα phase separation
Hardy JC, Pool EH, Bruystens JGH et al. (2024) | Molecular Cell
Nicheformer: a foundation model for single-cell and spatial omics
Anna C. Shaar, Alejandro Tejada-Lapuerta, Giovanni Palla et al. (2024) | bioRxiv
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, U.N., Jiang, J., Dalton, T.C. et al. (2024) | Nature
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
Sahba Seddighi, Yue A. Qi, Anna-Leigh Brown et al. (2024) | Science Translational Medicine
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age
Steven Wells, Daniel Rainbow, Michael Mark et al. (2024) | bioRxiv
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
Adam Glaser, Jayaram Chandrashekar, Joshua Vasquez et al. (2024) | eLife
A spatially resolved single-cell genomic atlas of the adult human breast
Kumar, T., Nee, K., Wei, R. et al. (2023) | Nature
Public engagement with biomedical science: An analysis of Black, Hispanic, and General Population adults in the United States
Adina Abeles, Kishore Hari, Cory Manento et al. (2023) | bioRxiv