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Lattice Light Sheet Microscopy of Living Cells

Award Imaging Scientist

Funding Cycle Cycle 1


Brandon Scott, PhD

South Dakota School of Mines and Technology, SDSMT (BioSystems Networks & Translational Research, BioSNTR)


Dr. Scott earned his PhD in biochemistry from South Dakota State University in 2015, working with Dr. Adam Hoppe. His graduate and postdoctoral research focused on the development and application of advanced microscopy methods investigating cellular dynamics, protein-protein interactions, image processing, and advanced analysis of microscopy data. He is a postdoctoral researcher in the BioSNTR imaging core, a team science center that includes biologists, microscopists, and computer scientists working together to develop gene-edited cell lines expressing fluorescent protein fusions to image molecular activities within living cells.

Project Description

Dr. Scott will assume the role of Research Assistant Professor in Nanoscience and Nanoengineering at SDSMT, and will lead the development and application of the facility’s recently constructed lattice light sheet microscope, licensed under an agreement with Howard Hughes Medical Institute. He will be responsible for teaching users about instrumentation and experimental design, along with facilitating sample preparation, image acquisition, data processing, and quantitative analysis. He will also facilitate collaborations to explore the nuances of living cells and membrane dynamics and probe the genetic basis of cellular function.