Project
Enabling a New Type of Microscopy for Ultradeep Imaging
Award
Deep Tissue Imaging Phase 1
Project Summary
Imaging at high spatial resolution requires the coherent addition of a wide range of spatial frequencies. This project will push imaging to depths greater than one centimeter in tissue at optical resolution by enabling a new type of microscopy that coherently amplifies the image field produced through nonlinear optical scattering. This strategy will measure a nonlinear distortion operator (NDO) from which high-resolution images will be extracted. The NDO will be a new mechanism for suppressing multiply scattered light to boost the relative fraction of single scattered to multiply scattered light, which will translate into a significantly increased imaging depth.
Investigators
Principal Investigator
![Randy Bartels, PhD](https://chanzuckerberg.com/wp-content/uploads/2020/11/randy-bartels.jpg)
Randy Bartels, PhD
Co-Principal Investigators
![Jeffrey Field, PhD](https://chanzuckerberg.com/wp-content/uploads/2020/11/jeffrey-field.jpg)
Jeffrey Field, PhD
![Christian Puttlitz, PhD](https://chanzuckerberg.com/wp-content/uploads/2020/11/Christian-Puttlitz-Headshot-2-e1605888411382.jpg)
Christian Puttlitz, PhD