Enabling a New Type of Microscopy for Ultradeep Imaging

Imaging at high spatial resolution requires the coherent addition of a wide range of spatial frequencies. This project will push imaging to depths greater than one centimeter in tissue at optical resolution by enabling a new type of microscopy that coherently amplifies the image field produced through nonlinear optical scattering. This strategy will measure a nonlinear distortion operator (NDO) from which high-resolution images will be extracted. The NDO will be a new mechanism for suppressing multiply scattered light to boost the relative fraction of single scattered to multiply scattered light, which will translate into a significantly increased imaging depth.