Frontiers of Imaging

Innovations in scientific imaging technologies such as ultrasound, MRI, photoacoustic, optical, X-ray, and quantum imaging could be transformative for biomedical applications and for understanding life at the cellular level. The Frontiers of Imaging effort supports technology development to allow researchers to peer deep into tissues in order to better understand and cure disease. Read more.

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Anatomical to Cellular Synchrotron Imaging of the Whole Human Body
Award Deep Tissue Imaging

This project will achieve transformations in X-ray tomography technology by enabling cellular-level imaging anywhere in whole organisms, including human bodies, providing insight at multiple anatomical levels.

Biomolecular Ultrasound for Deep Tissue Imaging of Cellular Functions
Award Deep Tissue Imaging

This project will develop genetically encodable biomolecular tools that will enable ultrasound to image specific cellular functions deep inside the body.

Combining Light and Sound for Deep Fluorescence Microscopy
Award Deep Tissue Imaging

This project will use a novel, multidisciplinary approach aimed at overcoming the current limitations of wavefront shaping microscopy to enable truly deep biological imaging.

Computational Microscopy with Multiple-Scattering Samples
Award Deep Tissue Imaging

This team will apply new computational microscopy techniques to reconstruct a sample’s 3D light scattering potential and digitally correct scattering effects.

Deep Tissue Short-Wave Infrared Multiphoton Microscopy
Award Deep Tissue Imaging

This project will pioneer short-wave infrared multiphoton microscopy, transforming intravital microscopy into a non-invasive technology.

Enabling a New Type of Microscopy for Ultradeep Imaging
Award Deep Tissue Imaging

This project will revolutionize the imaging depth with light at optical wavelength resolution by developing a new type of microscopy that uses nonlinear holography for ultradeep tissue imaging.

Megapixel Ultrasound Scanners for Deep Tissue Cellular Imaging
Award Deep Tissue Imaging

This project will use high-speed camera and laser technology to create contactless ultrasound arrays, able to image centimeters into tissue and at cellular resolution.

Nonlinear and Multimolecular Deep Tissue Ultrasound Imaging
Award Deep Tissue Imaging

This project will develop new ultrasound techniques for deep tissue imaging of cell types, cellular interactions, and cancers.

Obtaining Deep Tissue Data Using MRI Microcytometry
Award Deep Tissue Imaging

This team will develop magnetic resonance microscopy that combines novel data acquisition approaches, image reconstructions, gradient and cryogenic radiofrequency coil technologies, and ultra-high field strength to obtain unique cellular information in disease models.

Pushing the Limit of Photoacoustic Imaging
Award Deep Tissue Imaging

This project will develop a comprehensive toolbox of genetic near-infrared photochromic photoacoustic probes, acoustic-tunnel enhanced light delivery, and stochastic localization of photoacoustic probes in order to push the resolution limit of photoacoustic imaging.

Quantum Multi-Photon Excitation Microscopy for Deep Tissue Imaging
Award Deep Tissue Imaging

This project will develop quantum multi-photon excitation microscopy for centimeter-scale deep tissue imaging in complex organisms.

Short Wavelength Infrared 2-Photon Microscopy for Deep Tissue Imaging
Award Deep Tissue Imaging

This project will develop new near-infrared emitters and dual infrared 2-photon imaging technologies for deep tissue subcellular-scale imaging in brain and plant tissues.

Single-Cell Photoacoustic Molecular Imaging at Centimeter Depth
Award Deep Tissue Imaging

This project will develop and validate a super-resolution photoacoustic imaging technology using a revolutionary ultrasensitive nanophotonic sensor that enables single-cell resolution molecular imaging at centimeter depth in vivo.

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