Patient-Partnered Collaborations for Single-Cell Analysis of Rare Inflammatory Pediatric Disease RFA Grantees
CZI invited applications from collaborative teams bringing together patient-led rare disease organizations and research teams for four-year research projects aimed at advancing our understanding of the fundamental biology underlying rare diseases. The Patient-Partnered Collaborations for Single-Cell Analysis of Rare Inflammatory Pediatric Disease RFA aims to support the application of single-cell biology methods to rare inflammatory pediatric diseases to clarify cellular mechanisms of disease, understand disease heterogeneity, and improve biomarker identification or diagnostics. Patients are centered in this work. Each team is led by a Coordinating Primary Investigator (PI) and Patient Organization PI. Read about the grantees below.
Integrating Patients to Accelerate the Science Towards a World without NEC
to apply single-cell methodology to understand the cellular and molecular pathophysiology of neonatal necrotizing enterocolitis, a devastating disease affecting medically fragile infants
Coordinating PI: Misty Good
University of North Carolina at Chapel Hill
Patient Organization PI: Jennifer Canvasser
NEC Society
Scott Magness
University of North Carolina at Chapel Hill
Troy Markel
Indiana University School of Medicine
Camilia Martin
Weill Cornell Medicine
Amy Hair
Baylor College of Medicine
Understanding the Cellular Ecosystem of Primary Sclerosing Cholangitis
to understand the cellular ecosystem of the rare liver disease primary sclerosing cholangitis and identify potential cellular targets for effective therapies
Coordinating PI: Sonya MacParland
University Health Network
Patient Organization PI: Ruth-Anne Pai
PSC Partners Seeking a Cure
Gary Bader
University of Toronto
Amanda Ricuitto
Hospital for Sick Children
Creating an Inflammatory Childhood Interstitial Lung Disease Cell Atlas
to develop an open source atlas of childhood inflammatory interstitial lung diseases at single-cell resolution of children of diverse ancestries
Coordinating PI: John Christopher Kennedy
Boston Children’s Hospital/Harvard Medical School
Patient Organization PI: Heather Thompson
Children’s Interstitial and Diffuse Lung Disease (chILD) Foundation
Martha Potts Fishman
Boston Children’s Hospital/Harvard Medical School
James Hagood
University of North Carolina-Chapel Hill
Benjamin Raby
Boston Children’s Hospital/Harvard Medical School
Deciphering RUNX1-Familial Platelet Disorder at Single-Cell Resolution
to elucidate cellular processes responsible for inflammatory disease in RUNX1-Familial Platelet Disorder by leveraging single-cell multi-omic and spatial transcriptomic technologies
Coordinating PI: Alexander Bick
Vanderbilt University Medical Center
Patient Organization PI: Katrin Ericson
RUNX1 Research Program
Anupriya Agarwal
The Knight Cancer Institute, Oregon Health & Science University
Esther Obeng
St. Jude Children’s Research Hospital
Developing a Single-Cell Atlas to Accelerate Precision Medicine in Juvenile Dermatomyositis
to create a juvenile dermatomyositis single-cell, cross-tissue atlas to accelerate precision medicine via partnering with an international research network and diverse patient communities
Coordinating PI: Jessica Turnier
University of Michigan
Patient Organization PI: Andrew Heaton
Cure JM
Gabriela Fragiadakis
University of California, San Francisco
J. Michelle Kahlenberg
University of Michigan
Jessica Neely
University of California, San Francisco