The Childhood Hematopoiesis and Immune Development Atlas
The first years of life are critical for establishing protective immunity without inducing allergy, atopy, autoimmune disease, or malignant transformation. The Childhood Hematopoiesis and Immune Development Atlas (CHIDA) will map this complex process at a single-cell resolution. Specific attention will be paid to early development, where some of the most critical changes occur. In addition, the team will aim to over-represent donors of historically excluded ancestries. This is particularly important as underrepresented populations bear a disproportionate burden of disease and face worse outcomes.
Open source computational tools will be used to create dynamic, multi-omic maps of the developing hematopoietic and immune system at both spatial and temporal resolution. In addition, metabolic labeling and signal transduction network inference will allow constructing networks of cellular crosstalk within and across organs as well as their dynamic regulation in the developing child.