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Project

Human Breast Cell Atlas Seed Network


Focus Breast
Method Epigenetic Sequencing, Single Cell Transcriptomics, Spatial Genomics

Project Summary

This project will establish a comprehensive reference of cell types and cell states in human breast tissue with single cell and spatial resolution.


Results & Resources

A significant milestone for this team was the publication of the human breast cell atlas, including single-cell RNA-sequencing data and spatial transcriptomic data from 50 breast samples. This dataset identified and spatially mapped 12 different cell types, over 38 cell states, and found associations between transcriptomes, age, germline mutations, and BMI. This study will continue to serve as an essential reference when studying diseases such as breast cancer.


Investigators

Co-Principal Investigators
Ken Chen, PhD
Ken Chen, PhD
Kai Kessenbrock, PhD
Kai Kessenbrock, PhD

Devon Lawson, PhD
Devon Lawson, PhD
Je Lee, MD, PhD
Je Lee, MD, PhD

Bora Lim, MD
Bora Lim, MD
Nicholas Navin, PhD
Nicholas Navin, PhD