A Force-Directed Graph Interface for HCA Data Visualization and Exploration

To develop SPRING, a tool that allows users to interactively explore topology and gene expression features in high-dimensional single-cell data using force-directed graph layouts.

The Klein lab extended a nascent tool, SPRING, that improves the visualization of single-cell RNA-seq data. They created openly available tutorials and a server implementing SPRING. Additionally, they generated benchmark data for training trajectory inference methods, as further described in their preprint.