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Integrated Computational and Experimental Approaches to Dissect Cell Type Variation

Focus Brain

Project Goal

To dissect cell-type variation in human substantia nigra and locus coeruleus using integrated computational and experimental approaches.

Results & Resources

Macosko and Costa generated pilot data from difficult regions of the brain that are critical for neurodegeneration – the substantia and locus coeruleus. They released a protocol detailing frozen nuclei extraction and they have developed a computational tool (LIGER) to integrate diverse data types. This work is described in a preprint available on bioRxiv.


Lead Investigator

Evan Macosko
Evan Macosko

Co-Principal Investigators

Rui Costa
Rui Costa