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Multi-Scale Dissection of Rare Human Cellular Hierarchies

Focus Immune

Project Goal

To develop technologies simultaneously with analysis of the hematopoietic variation in a cohort of normal patients, and to examine how the platform scales when diverse samples from individuals of different clinical backgrounds are assessed.

Results & Resources

During this project, the Amit lab developed an experimental pipeline, MARS-seq2.0, and a computational pipeline, MetaCell, that combines unbiased sampling of transcriptional states using standard droplet technology with multi-faceted analysis of RNA and protein markers using index sorting. This work is described in a preprint available on bioRxiv.


Lead Investigator

Ido Amit
Ido Amit