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Reconstruction of Cellular Trajectories via Optimal Transport

Focus Trajectories

Project Goal

To develop optimal transport-based algorithms to reconstruct and visualize cell trajectories, fates and ancestors, alongside temporal processes such as differentiation, division or tumorigenesis.

Results & Resources

The Rigollet lab developed a novel conceptual and mathematical framework for understanding the temporal dynamics of development based on snapshots of expression profiles from heterogeneous cell populations undergoing dynamic transitions. They implemented this framework in a software package, Waddington-OT, with step-by-step tutorials.


Lead Investigator

Philippe Rigollet
Philippe Rigollet