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The Draft Human Immune Census

Focus Populations

Project Goal

To use multiplexed single-cell RNA-sequencing to construct a provisional version of the Human Immune Census across three ethnicities and to develop a new suite of computational tools to analyze the resulting data.

Results & Resources

The Ye lab developed experimental and computational tools to perform and analyze multiplexed single-cell RNA-seq and CITE-seq, data for which is openly available. They also developed computational tools demuxlet and freemuxlet which allow for deconvoluting single-cell transcriptomic data based on natural genetic variants, even without extra genotyping of biological samples.


Lead Investigator

Jimmie Ye
Jimmie Ye