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The Rosetta Project: Translating Data Across Single-Cell Technologies to Define Human Cell Types

Focus Multiomics

Project Goal

To map connections between a cell’s morphology and its transcriptome towards uncovering quantitative and predictive links among the various modalities.

Results & Resources

In this project, the Carpenter lab tested the hypothesis that relationships between cell morphology and mRNA levels can be learned by harmonizing single-cell morphology measurements with population-level mRNA measurements. They gathered parallel morphology and mRNA data, using three types of Cell Painting profiles, the data for which is publicly available.


Lead Investigator

Anne Carpenter
Anne Carpenter