The Rosetta Project: Translating Data Across Single-Cell Technologies to Define Human Cell Types

To map connections between a cell’s morphology and its transcriptome towards uncovering quantitative and predictive links among the various modalities.

In this project, the Carpenter lab tested the hypothesis that relationships between cell morphology and mRNA levels can be learned by harmonizing single-cell morphology measurements with population-level mRNA measurements. They gathered parallel morphology and mRNA data, using three types of Cell Painting profiles, the data for which is publicly available.