Human Vascular Endothelial Cell Atlas in the Young and Old

This network is contributing to an endothelial cell atlas in space and time by mapping the transcriptomes of endothelial cells from several tissues from donors of different ages and developing cutting-edge computational tools. To expand the racial diversity of this atlas, the project will include samples from Black and Latinx donors, which will help to clarify how cardiovascular disease manifests differently among various populations.

This Network was awarded the CZI Seed Networks Incentive to Support Diversity for the Human Cell Atlas.

This project focused on developing and optimizing new software to analyze the spatial transcriptome of blood vessels. They created Giotto, an open-source toolbox designed for spatial transcriptomic data analysis and visualization. Giotto enabled the publication of an integrated dataset of single-cell RNA-sequencing data and spatial transcriptomic data from mesenteric arteries.