Mapping Cells and Interactions in the Thymus Across Development and Aging

This project brings together scientists with broad and complementary expertise to generate a comprehensive cell atlas of the human thymus across development and aging.

This group generated bulk RNA-seq, ATAC-seq, and ChIP-seq datasets of the human postnatal thymus, as well as a single-cell RNA-seq dataset of human CD34+ thymocytes. They developed an approach to integrate multimodal data to classify the cell pairs and used this approach to integrate single-cell RNA-seq and single-cell ATAC-seq data across the developmental trajectory of the human fetal thymus.