Mapping the Human Adipose Tissue Cells and Intercellular Communication

This network will characterize the single nucleus transcriptomes and intercellular communication networks of human adipose tissue cells (adipocytes and stroma-vascular cells) across fat depots, sex, and ethnicity.

This project generated annotated cellular atlases of visceral and subcutaneous adipose tissues across sex and Jewish and Arab-Bedouins ethnicities. Initial progress toward these atlases identified new subset-specific marker genes and a list of receptors and ligands expressed in this subset, uncovering new intercellular communication signals used by adipose tissue cells.