Role of White Matter and Cerebrovascular Aging in Neurodegeneration
Aging is accompanied by white matter degeneration, and progressive demyelination is a feature of a number of neurodegenerative disorders, such as multiple sclerosis. However, it is not known how aging contributes to demyelination. This project will study age-related dysfunction of the cerebrovascular system and in particular, how deficits in the interactions of glia, vasculature, and microglia underlie myelin degeneration in aging. This team will combine single-cell transcriptomics with Correlative Light Electron Microscopy (CLEM) to correlate transcriptional changes with structural changes at the nanoscale level, as well as examine changes in microglia, glia, myelin, and vasculature during white matter degeneration.