Neurodegeneration Challenge Network

CZI’s Neurodegeneration Challenge Network brings together experimental scientists from diverse research fields, along with computational biologists and physicians, to understand the fundamental biology of neurodegenerative diseases and develop new strategies for treatment and prevention.

Two large, green, star-shaped cells appear with tree-like tendrils against a dark background.
A 3D illustration of astrocytes, star-shaped glial cells in the brain that connect neuronal cells to blood vessels.
A 3D illustration of astrocytes, star-shaped glial cells in the brain that connect neuronal cells to blood vessels.

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Showing 26 results

Assembling Human Cellular Models to Study Neurodegeneration
Investigators

Sergiu Pasca, MD, PhD - Stanford University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Bacterial and Toxin Engineering to Treat Motor Neuron Degeneration
Investigators

Isaac Chiu, PhD - Harvard Medical School

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD
Computational Discovery to Accelerate Neurodegenerative Disease Research
Investigators

Debora Marks, PhD - Harvard University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Creating and Deploying a Toolkit for Human Microglia in Neurodegeneration
Investigators

Philip L. De Jager, MD, PhD - Columbia University (Lead and Clinical PI)

Elizabeth Bradshaw, PhD - Columbia University

Vilas Menon, PhD - Columbia University

Vladislav Petyuk, PhD - Pacific Northwest National Laboratory

Award Collaborative Science Awards (2019-2021)
Disease Alzheimer’s Disease, General Neurodegeneration
Deciphering the Mechanisms of RNA-Mediated Toxicity in Neurodegeneration
Investigators

Mitchell Guttman, PhD - California Institute of Technology

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD
Decoding the Systems Pharmacology of Proteinopathy in Human Cells
Investigators

Michael Keiser, PhD - University of California, San Francisco

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Elucidating Cellular Mechanisms of Neurodegeneration by Functional Genomics
Investigators

Martin Kampmann, PhD - University of California, San Francisco

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Gridlock in the Nervous System: Altered RNA Localization and Local Translation in Neurodegeneration
Investigators

Eric Wang, PhD - University of Florida

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD, Huntington’s Disease
High-Throughput “3D” Profiling of Single T-cells in Neurodegenerative Diseases
Investigators

Ning (Jenny) Jiang, PhD - The University of Texas at Austin

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Human Cell-Based Models for Bridging the Gap Between Genetics and Pathology
Investigators

William Seeley, MD, PhD - University of California, San Francisco (Lead and Clinical PI)

Steven Altschuler, PhD - University of California, San Francisco

Aimee Kao, MD, PhD - University of California, San Francisco

Lani Wu, PhD - University of California, San Francisco

Award Collaborative Science Awards (2019-2021)
Disease ALS, General Neurodegeneration
Identifying the Role of Astrocytes in Neuronal Synapse Loss and Repair in Neurodegenerative Disease
Investigators

Nicola Allen, PhD - Salk Institute for Biological Studies

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease, General Neurodegeneration
Investigating Mechanisms of Tau-Mediated Neurodegeneration in the Human Brain
Investigators

Inma Cobos, MD, PhD - Stanford University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease, General Neurodegeneration
Investigation of Nuclear Pore Complex Alterations in ALS/FTD
Investigators

Gene Yeo, PhD - University of California, San Diego (Lead PI)

Jeffrey D. Rothstein, MD, PhD - Johns Hopkins University (Clinical PI)

Award Collaborative Science Awards (2019-2021)
Disease ALS, FTD
Mapping Cellular Networks for Microbiome Contributions to Neurodegeneration
Investigators

Elaine Hsiao, PhD - University of California, Los Angeles

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Mechanisms of Blood-Brain Barrier Transporter Regulation: New Avenues for Understanding and Treating Neurodegenerative Disorders
Investigators

Ethan Lippmann, PhD - Vanderbilt University

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Molecular Mechanisms of the Central Regulator of TREM2 Dysfunction
Investigators

Celeste Karch, PhD - Washington University in St. Louis (Lead PI)

Gregory Day, MD - Mayo Clinic, Florida (Clinical PI)

Carlos Cruchaga, PhD - Washington University in St. Louis

Oscar Harari, PhD - Washington University in St. Louis

Award Collaborative Science Awards (2019-2021)
Disease Alzheimer’s Disease
Neuron-Derived Extracellular Vesicles for Biomarker Discovery in Neurodegeneration
Investigators

David Walt, PhD - Harvard University (Lead PI)

Alice-Chen Plotkin, MD - University of Pennsylvania (Clinical PI)

George Church, MD - Harvard University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Non-Canonical Pathways Towards Rescue from Neurodegenerative States
Investigators

Viviana Gradinaru, PhD - California Institute of Technology

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
Probing Parkinson’s Disease with Induced Human Microcircuits on CMOS Chips
Investigators

Patrik Verstreken, PhD - VIB-KU Leuven (Lead PI)

Wim Vandenberghe, MD, PhD - KU Leuven (Clinical PI)

Dries Braeken, PhD - imec Leuven

Birgitt Schuele, MD - Stanford University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Profiling and Defining Parkinson’s Disease
Investigators

Ernest Arenas, MD, PhD - Karolinska Institutet (Lead PI)

Per Svenningsson, MD, PhD - Karolinska Institutet (Clinical PI)

Sten Linnarsson, PhD - Karolinska Institutet

Mats Nilsson, PhD - Stockholm University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Retrotransposon Reactivation in Neurodegenerative Disease
Investigators

Molly Gale Hammell, PhD - Cold Spring Harbor Laboratory

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease ALS, FTD
Role of Dysfunctional Astrocyte-Neuron Signaling in Parkinson’s Disease
Investigators

Cagla Eroglu, PhD - Duke University (Lead PI)

Nicole Calakos, MD, PhD - Duke University (Clinical PI)

Albert La Spada, MD, PhD - Duke University

Award Collaborative Science Awards (2019-2021)
Disease Parkinson’s Disease
Targeting Shared Mechanisms in Neurodegenerative and Metabolic Disease
Investigators

Florian T. Merkle, PhD - University of Cambridge

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease, General Neurodegeneration, Parkinson’s Disease
The Innate Immune System in Neurodegeneration
Investigators

Ivan Marazzi, PhD - Icahn School of Medicine at Mt. Sinai, New York

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration
The Structural Basis of Protein Pathology in Tauopathy
Investigators

Marc Diamond, MD - UT Southwestern Medical Center (Lead PI)

Charles White, MD - UT Southwestern Medical Center (Clinical PI)

Lukasz Joachimiak, PhD - UT Southwestern Medical Center

Award Collaborative Science Awards (2019-2021)
Disease Alzheimer’s Disease, FTD
Viral-Like Mechanisms of Intercellular Communication in the Pathology of Neurodegeneration
Investigators

Jason Shepherd, PhD - The University of Utah

Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease Alzheimer’s Disease

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