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The Role of Pink1/Parkin in the Intestinal Epithelium

Award Collaborative Pairs Pilot Project Awards (Cycle 1) (Phase 1)
Focus Area Neurodegeneration

Project Description

Recent studies have suggested a potential connection between the gut and neurodegeneration in Parkinon’s disease. The Parkinson’s associated genes Pink1/Parkin have been implicated in mitochondrial function of neurons, but are also expressed in the gut, although little is known about their functional role. This team will use colon biopsy-derived human tissue cultures and organoids to investigate the role of Pink1/Parkin signaling in mitochondrial function in the intestinal epithelium.

Investigators

Ming Guo, MD, PhD
Ming Guo, MD, PhD

University of California, Los Angeles

Elizabeth J. Videlock, MD, PhD
Elizabeth J. Videlock, MD, PhD

University of California, Los Angeles

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