The Role of Pink1/Parkin in the Intestinal Epithelium
Award Collaborative Pairs Pilot Project Awards (Phase 1) (2020) (2020)
Disease Parkinson’s Disease
Recent studies have suggested a potential connection between the gut and neurodegeneration in Parkinon’s disease. The Parkinson’s associated genes Pink1/Parkin have been implicated in mitochondrial function of neurons, but are also expressed in the gut, although little is known about their functional role. This team will use colon biopsy-derived human tissue cultures and organoids to investigate the role of Pink1/Parkin signaling in mitochondrial function in the intestinal epithelium.
Ming Guo, MD, PhD
Elizabeth J. Videlock, MD, PhD