Probing Parkinson’s Disease with Induced Human Microcircuits on CMOS Chips
There currently are no drugs that slow down or stop the progression of Parkinson’s disease. The key limitation to understanding and treating neurodegenerative disorders such as Parkinson’s is the lack of disease models that reproduce all clinically relevant aspects of these diseases. Therefore, we will develop the technology to produce mature human neuronal microcircuits relevant to Parkinson’s disease on a multi-electrode array chip. Using the chip’s built-in recording circuitry, we will be able to compare the induced neuronal circuits of cells obtained from healthy people and from an extensive collection of Parkinson patients. This unique platform will allow us to test the role of pathogenic pathways on neuronal network dysfunction and screen for novel therapeutic approaches.