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Neuroimmune Crosstalk Along the Gut-Brain Axis in Parkinson’s Disease


Award Collaborative Pairs Pilot Project Awards (2020)
Disease Parkinson’s Disease

Project Description

Emerging data suggest a role for the gut-brain axis and neuroinflammation in the development of Parkinson’s disease, but the mechanisms by which gut pathology relates to brain pathology are not clear. This project will study a potential role for the Parkinson’s associated gene, LRRK2, in gut macrophages and signaling in the enteric nervous system. The team brings together expertise in neuroimmunology, alpha-synuclein biochemistry, and cell biology to profile gut macrophages in both mouse models and human samples to assess their role in alpha-synuclein spread from the gut and enteric nervous system to the central nervous system.

This project was selected for the second phase of the Collaborative Pairs RFA.


Investigators

Tim Bartels
Tim Bartels
Soyon Hong
Soyon Hong
Dario Alessi
Dario Alessi
Kenneth Harris
Kenneth Harris
Neil Ranson
Neil Ranson