The Innate Immune System in Neurodegeneration

Our scientific goal is twofold. First, we want to understand the pathogenic mechanisms of mutant proteins in neurodegeneration. Second, we aim to test the hypothesis that neurodegenerative diseases can be instigated or accelerated by dysfunction of the innate immune system. Our study has an important therapeutic implication, as its findings may provide a rationale for targeting the innate immune system to decelerate or even eradicate neurodegenerative diseases.