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Assembling Human Cellular Models to Study Neurodegeneration


Award Ben Barres Early Career Acceleration Awards (2019-2023)
Disease General Neurodegeneration

Project Description

We propose to leverage technology we developed in the lab to build self-organizing 3D human cellular systems that capture neural-glial interactions and inter-regional neural cross-talk. We will use this powerful preparation, also known as brain assembloids, to uncover the programs underlying prolonged maturation of neurons and astrocytes in humans and model specific genetic forms of neurodegenerative disorders. This work could lead to novel strategies and tools for modeling brain maturation and neurodegeneration with patient-derived cells and could ultimately bring therapeutic insights.


Investigators

Sergiu Pasca, MD, PhD
Sergiu Pasca, MD, PhD