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Promoting Neuronal Cell Death to Mitigate Widespread Neurodegeneration


Award Collaborative Pairs Pilot Project Awards (2020)
Disease General Neurodegeneration

Project Description

Extensive cell death is a hallmark of neurodegenerative disease. Early cell death is typically limited and regional, and then spreads as the disease progresses. This project proposes a new way to think about neuronal cell death, investigating the idea that early cell death of diseased neurons may initially serve as a protective mechanism that slows disease spread. The team will also test the hypothesis that targeting these early “pathogenic” neurons for more rapid elimination may suppress disease progression.


Investigators

David Simon
David Simon
Trent Watkins
Trent Watkins