Investigation of Nuclear Pore Complex Alterations in ALS/FTD
Award
Collaborative Science Awards
Focus Area
Neurodegeneration
Project Description
Alterations in nucleocytoplasmic transport (NCT) have emerged as a prominent pathomechanism underlying multiple neurodegenerative diseases. However, the precise mechanism by which NCT is disrupted in neurodegeneration remains largely unknown. We will use iPSC technology and a combination of molecular, biochemical, and imaging approaches to determine cell type specific alterations in and the effect of ALS/FTD associated mutations on nuclear pores.
Investigators
![Gene Yeo, PhD](https://chanzuckerberg.com/wp-content/uploads/2020/05/gene_yeo.png)
Gene Yeo, PhD
![Jeffrey D. Rothstein, MD, PhD](https://chanzuckerberg.com/wp-content/uploads/2020/05/jeffrey_rothstein.jpg)
Jeffrey D. Rothstein, MD, PhD